Innovations in Pharmaceutical Sciences & Care

Background: Frontal hair loss is a common cosmetic and psychological concern among adult males and may result from androgenetic alopecia, occupational mechanical stress, environmental exposures, or a combination of these factors. Mesotherapy has emerged as a minimally invasive therapeutic approach that delivers nutrients and bioactive substances directly to hair follicles, while topical minoxidil remains a well-established treatment for promoting hair growth. Case Presentation: A 31-year-old male presented with progressive frontal hairline recession and temporal thinning associated with prolonged occupational use of protective headgear and exposure to a hot, humid coastal environment. Clinical examination revealed marked frontal and bitemporal recession with an M-shaped hairline pattern, diffuse thinning in the frontal-temporal regions, and increased scalp visibility. The patient underwent six sessions of scalp mesotherapy consisting of vitamins, minerals, amino acids, hyaluronic acid, vasodilatory agents, and growth-promoting peptides, combined with twice-daily application of 5% topical minoxidil. Clinical Outcome: Following six weeks of treatment, standardized photographic assessment demonstrated a substantial increase in frontal and temporal hair density, reduced scalp visibility, improved hairline uniformity, and enhanced follicular coverage. Improvements in hair texture and overall scalp appearance were also observed. The patient reported high satisfaction with the treatment outcome, with noticeable reduction in the characteristic M-shaped recession pattern.